The identification of polyoxyethylene glycols and related compounds by capillary gas chromatography

A sample work-up method for gas chromatographic profiling of polyoxyethylene glycol (PEG)-related compounds in pharmaceutical matrices is described. After a short sample clean-up, carbon—oxygen linkages are partially cleaved with 0.07 M boron tribromide in dichloromethane at room temperature. The re...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1990, Vol.8 (8), p.919-927
Main Authors: Leyssens, L., Martens, V., Royackers, E., Penxten, H., Verheyden, A., Czech, J., Raus, J.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
capillary gas chromatography
Chromatography, Gas
Gas Chromatography-Mass Spectrometry
General pharmacology
Indicators and Reagents
Medical sciences
Molecular Weight
non-ionic surfactants
pharmaceutical adjuvants
Pharmacology. Drug treatments
Polyethylene glycol and related compounds
Polyethylene Glycols - analysis
Solvents
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Summary:A sample work-up method for gas chromatographic profiling of polyoxyethylene glycol (PEG)-related compounds in pharmaceutical matrices is described. After a short sample clean-up, carbon—oxygen linkages are partially cleaved with 0.07 M boron tribromide in dichloromethane at room temperature. The reaction is stopped after 1 min by addition of 0.01 M HCl. The products are trimethylsilylated and injected onto a WCOT 50 m × 0.25 mm CP-SIL 5 CB fused silica column. Eleven model compounds, representing four common types of PEG-derivatives, have been evaluated by this method. The results show that characteristic profiles can be obtained from PEG-derivatives carrying different functional groups. Minimum detectable amounts are in the range of 200 μg.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(90)80143-D