Cellulose Acetate Membrane Improves Some Aspects of Red Blood Cell Function in Haemodialysis Patients

The present study was designed to evaluate the influence of two haemodialysis membranes of different biocompatibility on red blood cell function. Twelve patients were studied in two consecutive dialyses, with cuprophan and cellulose acetate. Blood was extracted at 0, 20 and 180 min after the beginni...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1990, Vol.5 (7), p.497-499
Main Authors: Sevillano, G., Rodriguez-Puyol, M., Martos, R., Duque, I., Lamas, S., Diez-Marqués, M. L., Lucio, J., Rodríguez-Puyol, D.
Format: Article
Language:English
Subjects:
Adult
Anaemia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biocompatibility
Biocompatible Materials
Biological and medical sciences
Cellulose - analogs & derivatives
Cellulose acetate
Deformability
Emergency and intensive care: renal failure. Dialysis management
Erythrocyte Deformability - drug effects
Erythrocytes - physiology
Female
Hematocrit
Hemoglobins - analysis
Hemolysis - drug effects
Humans
Intensive care medicine
Kidneys, Artificial
Male
Malondialdehyde - blood
Medical sciences
Membranes, Artificial
Methemoglobin - metabolism
Middle Aged
Osmotic Fragility
Oxidant Stimuli
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Summary:The present study was designed to evaluate the influence of two haemodialysis membranes of different biocompatibility on red blood cell function. Twelve patients were studied in two consecutive dialyses, with cuprophan and cellulose acetate. Blood was extracted at 0, 20 and 180 min after the beginning of the haemodialysis session and general haematological parameters, osmotic fragility, deformability, methaemoglobin concentration and malonyldialdehyde (MDA) red blood cell content were determined. Osmotic fragility improved with both membranes, but this improvement was more marked with cellulose acetate. MDA red blood cell content showed a tendency to increase after 3h with cuprophan (114±11% of the basal value), whereas it tended to decrease with cellulose acetate (92±12%), the differences between the two groups being statistically significant. These results suggest that red cell function may improve by changing the characteristics of haemodialysis membranes. This phenomenon could be related to a better biocompatibility.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/5.7.497