T-Cell Surface Antigens in a Patient With Blast Crisis of Chronic Myeloid Leukemia

There is little evidence to suggest that T lymphocytes are involved in the leukemic process in chronic myeloid leukemia (CML). A case of CML in blast phase is described in which T-cell surface antigens were detected by immunofluorescence on the patient's blasts using monoclonal antibodies. In o...

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Bibliographic Details
Published in:Blood 1983-04, Vol.61 (4), p.640-644
Main Authors: Griffin, James D., Tantravahi, Ramana, Canellos, George P., Wisch, Jeffrey S., Reinherz, Ellis L., Sherwood, Geoffrey, Beveridge, Richard P., Daley, John F., Lane, Heather, Schlossman, Stuart F.
Format: Article
Language:English
Subjects:
Antigens, Surface - genetics
Antigens, Surface - immunology
Biological and medical sciences
Bone Marrow - pathology
Chromosomes, Human, 21-22 and Y
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid - immunology
Leukemia, Myeloid - pathology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Phenotype
T-Lymphocytes - immunology
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Summary:There is little evidence to suggest that T lymphocytes are involved in the leukemic process in chronic myeloid leukemia (CML). A case of CML in blast phase is described in which T-cell surface antigens were detected by immunofluorescence on the patient's blasts using monoclonal antibodies. In order to determine that the T-cell blasts were derived from the original CML clone, cells bearing the T3 antigen were isolated by fluorescence-activated cell sorting and chromosome analysis was performed. All metaphases examined had the Philadelphia chromosome, confirming their origin from CML.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V61.4.640.640