In-111 Oxine Autologous Labeled Platelets in the Diagnosis of Kidney Graft Rejection

The usefulness of ln-111 oxine labeled autologous platelets in the diagnosis of renal graft rejection was studied. The method is based on imaging of the graft area at 4, 24, 48, and 72 hours after the injection of the labeled cells. The study was done in 31 renal transplant recipients. The control g...

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Bibliographic Details
Published in:Clinical nuclear medicine 1983-01, Vol.8 (1), p.7-10
Main Authors: MARTIN-COMIN, J, ROCA, M, GRINO, J M, PARADELL, C, CARALPS, C
Format: Article
Language:English
Subjects:
Adult
Blood Platelets
Evaluation Studies as Topic
False Positive Reactions
Female
Graft Rejection
Humans
Hydroxyquinolines
Indium
Kidney - diagnostic imaging
Kidney - physiopathology
Kidney Transplantation
Kidney Tubular Necrosis, Acute - diagnostic imaging
Male
Middle Aged
Organometallic Compounds
Oxyquinoline - analogs & derivatives
Radioisotopes
Radionuclide Imaging
Time Factors
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Summary:The usefulness of ln-111 oxine labeled autologous platelets in the diagnosis of renal graft rejection was studied. The method is based on imaging of the graft area at 4, 24, 48, and 72 hours after the injection of the labeled cells. The study was done in 31 renal transplant recipients. The control group included four patients with normal renal function without evidence of rejection. No platelet uptake was observed in any of them. The study group included 22 patients with acute rejection which was confirmed histologically in 13. One case of chronic vascular type rejection of the graft tracer uptake was seen. There was a false-positive result due to a perirenal hematoma. In three patients with a nonimmunological sudden impairment of renal function, no activity was detected in the graft area. We also evaluated the changes in platelet trapping throughout the study and they seemed to correlate with the response to the antirejection therapy.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-198301000-00003