The clinical significance of placental villous edema

A study was undertaken to determine why there is such variability in morbidity and mortality in neonates exposed to antenatal chorioamnionitis. Villous edema provides a clue. It was present in 72/83 placentas with chorioamnionitis. The extent and severity of the edema had a strong, positive correlat...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1983-04, Vol.71 (4), p.588-593
Main Authors: Naeye, R L, Maisels, M J, Lorenz, R P, Botti, J J
Format: Article
Language:English
Subjects:
Amnion
Apgar Score
Chorion
Chorionic Villi - pathology
Edema - complications
Edema - pathology
Female
Fetal Blood
Fetal Hypoxia - etiology
Humans
Hydrogen-Ion Concentration
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases - etiology
Inflammation - complications
Placenta - pathology
Placenta Diseases - complications
Placenta Diseases - pathology
Pregnancy
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Summary:A study was undertaken to determine why there is such variability in morbidity and mortality in neonates exposed to antenatal chorioamnionitis. Villous edema provides a clue. It was present in 72/83 placentas with chorioamnionitis. The extent and severity of the edema had a strong, positive correlation with cord arterial blood pH values, low Apgar scores, the need to resuscitate vigorously at birth, the subsequent need for assisted ventilation, the frequency of hyaline membrane disease, and neonatal mortality. Most of the difference in morbidity and mortality between preterm and full-term infants was related to the greater severity and extent of villous edema in those born prematurely.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.71.4.588