Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the aminoterminal sequence of each being highly homologous to...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1991-02, Vol.251 (4995), p.788-791
Main Authors: Cybulsky, Myron I., Gimbrone, Michael A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Antibodies, Monoclonal
Aorta
Arteriosclerosis - etiology
Arteriosclerosis - metabolism
Atherosclerosis
Biological and medical sciences
Cardiovascular disease
Cell adhesion molecules
Cell Adhesion Molecules - biosynthesis
Cells, Cultured
Cellular biology
Development and progression
Diet, Atherogenic
Endothelium
Endothelium, Vascular - metabolism
Foam cells
Fundamental and applied biological sciences. Psychology
Lesions
Leukocytes
Leukocytes, Mononuclear - physiology
Lipopolysaccharides
Lymphocytes
Medical research
Miscellaneous
Molecular Sequence Data
Molecules
Monocytes
Mononuclear leukocytes
Proteins
Rabbits
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Summary:An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the aminoterminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1990440