Myocardial Sulfhydryl Pool Alterations Occur During Reperfusion After Brief and Prolonged Myocardial Ischemia In Vivo

Myocardial sulfhydryl (SH)-containing compounds, including reduced glutathione (GSH), are both defenses against and potential markers of reactive oxygen metabolite injury during ischemia and reperfusion. We examined the alterations in GSH and other myocardial SH pools during reperfusion in anestheti...

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Bibliographic Details
Published in:Circulation research 1991-02, Vol.68 (2), p.605-613
Main Authors: Lesnefsky, Edward J, Dauber, Ira M, Horwitz, Lawrence D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Coronary Disease - metabolism
Coronary heart disease
Dogs
Female
Glutathione - analogs & derivatives
Glutathione - metabolism
Glutathione Disulfide
Heart
Male
Medical sciences
Myocardial Reperfusion
Myocardium - metabolism
Sulfhydryl Compounds - metabolism
Time Factors
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Summary:Myocardial sulfhydryl (SH)-containing compounds, including reduced glutathione (GSH), are both defenses against and potential markers of reactive oxygen metabolite injury during ischemia and reperfusion. We examined the alterations in GSH and other myocardial SH pools during reperfusion in anesthetized dogs exposed to brief (15 minutes, n=7) or prolonged (90 minutes, n=6) regional ischemia caused by occlusion of the left anterior descending artery. Ninety minutes of ischemia followed by 5 hours of reperfusion, which resulted in myocardial necrosis of 43.9±4.0% of the area at risk, caused a 22% reduction in total myocardial SH groups (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.68.2.605