Differentiation in embryonal neuroepithelial tumors of the central nervous system

Ninety‐six embryonal neuroectodermal tumors were studied histologically and immunohistologically with a panel of antibodies including glial, neuronal, epithelial, mesodermal, and myelin markers. In 71 tumors there was glial and neuronal differentiation and expression both of an S (photoreceptor) ant...

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Bibliographic Details
Published in:Cancer 1991-02, Vol.67 (4), p.965-976
Main Authors: Cruz‐Sanchez, Felix F., Rossi, Marco L., Hughes, John T., Moss, Tim H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, Differentiation - analysis
Brain Neoplasms - pathology
Child
Child, Preschool
Ependymoma - pathology
Female
Ganglioneuroma - pathology
Glial Fibrillary Acidic Protein - analysis
Humans
Immunohistochemistry
Infant
Male
Medulloblastoma - pathology
Middle Aged
Neoplasms, Germ Cell and Embryonal - pathology
Nerve Tissue Proteins - analysis
Neuroblastoma - pathology
Pinealoma - pathology
Retinoblastoma - pathology
S100 Proteins - analysis
Spinal Cord Neoplasms - pathology
Vimentin - analysis
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Summary:Ninety‐six embryonal neuroectodermal tumors were studied histologically and immunohistologically with a panel of antibodies including glial, neuronal, epithelial, mesodermal, and myelin markers. In 71 tumors there was glial and neuronal differentiation and expression both of an S (photoreceptor) antigen and vimentin. In five tumors there was only glial differentiation and in 20 tumors only neuronal differentiation. No reactivity for myelin and epithelial markers was found. Histologic and immunohistologic findings identified various degrees of differentiation in different tumors, which was bipolar (glial and neuronal) in most tumors and unipolar in the remainder. The authors suggest that their findings may be the result of normal or aberrant oncogenic differentiation, agreeing with the nomenclature of the World Health Organization classification for these tumors with and the inclusion of a category for ependymoblastoma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19910215)67:4<965::AID-CNCR2820670419>3.0.CO;2-D