The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loophelix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The he...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1991-02, Vol.251 (4995), p.761-766
Main Authors: Weintraub, Harold, Davis, Robert, Tapscott, Stephen, Thayer, Matthew, Krause, Michael, Benezra, Robert, Blackwell, T. Keith, Turner, David, Rupp, Ralph, Hollenberg, Stanley, Zhuang, Yuan, Lassar, Andrew
Format: Article
Language:English
Subjects:
Animals
Binding sites
Biological and medical sciences
Cell differentiation
Cell Differentiation - genetics
Cell lines
Cells
Cellular biology
Chondrocytes
DNA
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genes
Genes, Regulator
Genetic aspects
Genetic regulation
Genetic transcription
Genetics
HeLa cells
Hep G2 cells
Humans
Molecular and cellular biology
Molecular genetics
Multigene Family
Muscle cells
Muscle development
Muscle Proteins - genetics
Muscle Proteins - physiology
Muscles - cytology
Muscles - embryology
Muscular system
MyoD Protein
Myogenesis
Neurons
Regulation
Transcription (Genetics)
Transcription. Transcription factor. Splicing. Rna processing
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Summary:The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loophelix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1846704