Blood vessels in Trichinella spiralis infections: a study using vascular casts

Larvae of Trichinella spiralis initiate the transformation of myocytes into nurse cells that become surrounded by elaborate networks of blood vessels. To examine the structure of these networks (i.e., retes), transcardic perfusion was used to clear the vascular tree of Trichinella-infected mice and...

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Bibliographic Details
Published in:The Journal of parasitology 1991-02, Vol.77 (1), p.99-103
Main Authors: Baruch, A.M. (City Hospital Center at Elmhurst, Elmhurst, NY), Despommier, D.D
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biological and medical sciences
BLOOD VESSELS
Cardiovascular system
Corrosion Casting
Helminthic diseases
Host Response and Pathogenesis
Infections
Infectious diseases
Larvae
Larval development
Male
Medical sciences
MICE
Miscellaneous
MUSCLE
Muscle larvae
MUSCLES
Muscles - blood supply
MUSCULOS
myocytes
nurse cells
Nurses
Parasitic diseases
Parasitology
Perfusion
RATON
rete
SKELETAL MUSCLE
SOURIS
TRICHINELLA SPIRALIS
Trichinellosis - pathology
VAISSEAU SANGUIN
VASOS SANGUINEOS
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Summary:Larvae of Trichinella spiralis initiate the transformation of myocytes into nurse cells that become surrounded by elaborate networks of blood vessels. To examine the structure of these networks (i.e., retes), transcardic perfusion was used to clear the vascular tree of Trichinella-infected mice and to inject a plastic that polymerized in situ. Vascular complexes were found only around infected myocytes and were characterized by large circumferential vessels that give rise to the smaller channels of the retes. The secondary vessels vary widely in caliber and are distributed in a random fashion. Three types of network were found: simple, complex, and hypercomplex, and they were distributed normally, with the complex retes the most common. Comparison of the structure of the baskets with that of vessels in surrounding uninfected muscle strongly suggests that the vascular retes are the result of de novo angiogenesis induced during the infection. The parasite may elicit angiogenesis directly through secretion of unique products or may elicit a change in the nurse cell that, in turn, results in growth of new blood vessels.
ISSN:0022-3395
1937-2345
DOI:10.2307/3282565