Effect of removal of zinc on alfalfa mosaic virus RNA-dependent RNA polymerase

The necessity of coat protein for infection of plants by alfalfa mosaic virus (AIMV) and other ilarviruses distinguishes this virus group from other plants virus groups, Recently, the presence of both a zinc-finger type motif and zinc in AIMV coat protein was described [(1989) Virology 168, 45–56]....

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Bibliographic Details
Published in:FEBS letters 1991-01, Vol.278 (1), p.61-62
Main Authors: Quadt, R., Jaspars, E.M.J.
Format: Article
Language:English
Subjects:
Autoradiography
Capsid - metabolism
Chelating Agents
Medicago sativa
Mosaic Viruses - enzymology
Phenanthrolines - pharmacology
RNA Replicase - antagonists & inhibitors
RNA Replicase - metabolism
Zinc - pharmacology
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Summary:The necessity of coat protein for infection of plants by alfalfa mosaic virus (AIMV) and other ilarviruses distinguishes this virus group from other plants virus groups, Recently, the presence of both a zinc-finger type motif and zinc in AIMV coat protein was described [(1989) Virology 168, 45–56]. We studied the effect of a zinc chelator on viral RNA synthesis. Strong inhibition of AIMV RNA-dependent RNA polymerase (RdRp) by ortho-phenanthroline (OP) was observed.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(91)80083-F