Ketamine as analgesic for total intravenous anaesthesia with propofol

Summary A prospective study of 18 patients who underwent noncardiac surgery was performed to study the use of ketamine as an analgesic during total intravenous anaesthesia with propofol. A comparison was made with the combination propofol/fentanyl. The propofol/ketamine combination resulted in haemo...

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Bibliographic Details
Published in:Anaesthesia 1991-01, Vol.46 (1), p.24-27
Main Authors: GUIT, J. B. M., KONING, H. M., COSTER, M. L., NIEMEIJER, R. P. E., MACKIE, D. P.
Format: Article
Language:English
Subjects:
Adjuvants, Anesthesia
Adult
Anaesthetics, intravenous
propofol, ketamine
Analgesics - pharmacology
Anesthesia, Intravenous
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Double-Blind Method
Female
Fentanyl - pharmacology
Hemodynamics - drug effects
Humans
Intraoperative Period
Ketamine - pharmacology
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Postoperative Complications - etiology
Propofol - pharmacology
Prospective Studies
Total intravenous anaesthesia
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Summary:Summary A prospective study of 18 patients who underwent noncardiac surgery was performed to study the use of ketamine as an analgesic during total intravenous anaesthesia with propofol. A comparison was made with the combination propofol/fentanyl. The propofol/ketamine combination resulted in haemodynamically stable anaesthesia without the need for additional analgesics. Postoperative behaviour was normal in all patients and none of the patients reported dreaming during or after the operation. Propofol seems to be effective in eliminating side effects of a subanaesthetic dose of ketamine in humans. We recommend the propofol/ketamine combination for total intravenous anaesthesia for surgery when stable haemodynamics are required.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1991.tb09308.x