PHARMACOKINETICS STUDY ON GENTAMICIN INTRAVENOUS DRIP INFUSION IN CHILDREN

Pharmacokinetics of gentamicin in children after intravenous infusion over 60 minutes were compared with that after intramuscular injection. 1. Mean measured peak serum levels after intravenous infusion of 2.5mg/kg and intramuscular injection of 2.0mg/kg were 6.1mu;g/ml at termination of infusion an...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1983/01/25, Vol.36(1), pp.47-54
Main Authors: SUNAKAWA, KEISUKE, AKITA, HIRONOBU, JOZAKI, KEIJI, IWATA, SATOSHI, IWASAKI, YUKIO, SATO, YOSHITAKE, TOJOH, MASAHIRO, WAKABAYASHI, RYO, HAYANO, SHINYA, OSANO, MITSURU, MATSUO, TAKEO, YAMADA, ZENZABURO, SUZUKI, HIROKO, ICHIHASHI, YASUO
Format: Article
Language:Japanese
Subjects:
Adolescent
Age Factors
Child
Child, Preschool
Female
Gentamicins - administration & dosage
Gentamicins - metabolism
Humans
Infant
Infusions, Parenteral
Injections, Intramuscular
Kinetics
Male
Time Factors
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Summary:Pharmacokinetics of gentamicin in children after intravenous infusion over 60 minutes were compared with that after intramuscular injection. 1. Mean measured peak serum levels after intravenous infusion of 2.5mg/kg and intramuscular injection of 2.0mg/kg were 6.1mu;g/ml at termination of infusion and 6.5mu;g/ml at 30 or 60 minutes after injection, respectively. Older children showed higher serum levels. 2. There was no difference in serum half-life between both modes of administration. 3. The AUC after intravenous infusion was slightly larger than that after intramuscular injection. 4. It was suggested that the efficacy and safety of the treatment by intravenous infusion in children are comparable to that by the intramuscular injection, and optimum single dose is 1.5-2.5mg/kg.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.36.47