Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression

Astrocytomas are highly malignant brain tumors and are among the most neovascularized solid tumors. We have investigated the expression of the angiogenic growth factors acidic fibroblast growth factor and transforming growth factor-alpha, together with its receptor epidermal growth factor receptor,...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1991-02, Vol.51 (4), p.1345-1351
Main Authors: MAXWELL, M, NABER, S. P, WOLFE, H. J, HEDLEY-WHYTE, E. T, GALANOPOULOS, T, NEVILLE-GOLDEN, J, ANTONIADES, H. N
Format: Article
Language:English
Subjects:
Angiogenesis Inducing Agents - biosynthesis
Astrocytoma - pathology
Biological and medical sciences
Blotting, Northern
Brain Neoplasms - pathology
Fibroblast Growth Factor 1 - biosynthesis
Humans
Immunohistochemistry
Medical sciences
Neovascularization, Pathologic
Neurology
Nucleic Acid Hybridization
Receptor, Epidermal Growth Factor - biosynthesis
RNA, Messenger - analysis
Transforming Growth Factor alpha - biosynthesis
Tumors of the nervous system. Phacomatoses
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Summary:Astrocytomas are highly malignant brain tumors and are among the most neovascularized solid tumors. We have investigated the expression of the angiogenic growth factors acidic fibroblast growth factor and transforming growth factor-alpha, together with its receptor epidermal growth factor receptor, in 30 primary astrocytomas. Both acidic fibroblast growth factor and transforming growth factor-alpha, together with epidermal growth factor receptor, are found to be greatly overexpressed in these tumors when compared with normal brain. This overexpression of angiogenic growth factors may underlie the intense neovascularization characteristic of astrocytomas.
ISSN:0008-5472
1538-7445