Inhibition of axonal growth by a monoclonal antibody

Little is known about factors which control the outgrowth of neurites in the central nervous system (CNS) during development, although in vitro studies with neurones from the peripheral nervous system have shown that neurites require an appropriate substrate 1 and specific factors 2,3 for growth. To...

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Bibliographic Details
Published in:Nature (London) 1983-05, Vol.303 (5912), p.65-67
Main Authors: Henke-Fahle, Sigrid, Bonhoeffer, Friedrich
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Axons - immunology
Axons - physiology
Cell Adhesion
Cells, Cultured
Chick Embryo
Growth Inhibitors
Humanities and Social Sciences
letter
multidisciplinary
Retina - embryology
Science
Science (multidisciplinary)
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Summary:Little is known about factors which control the outgrowth of neurites in the central nervous system (CNS) during development, although in vitro studies with neurones from the peripheral nervous system have shown that neurites require an appropriate substrate 1 and specific factors 2,3 for growth. To investigate the role of cell-surface components in the development of the CNS, we have raised a series of monoclonal antibodies against membrane components of cells from the visual system of the chick embryo. We report here that one of these antibodies, T61/3/12, clearly inhibits axonal outgrowth from chick retinal explants but does not affect axon growth from the peripheral nervous system.
ISSN:0028-0836
1476-4687
DOI:10.1038/303065a0