Etiologic Studies of Epidemic Hemorrhagic Fever (Hemorrhagic Fever with Renal Syndrome)

Two strains of epidemic hemorrhagic fever (EHF) virus were isolated from the lung tissues of Apodemus agrarius mice that were captured in an area where EHF is endemic. The strains were isolated by passages in A. agrarius mice from a nonendemic area. Identification of the isolates by usual procedures...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-04, Vol.147 (4), p.654-659
Main Authors: Song, Gan, Hang, Cbang-sbou, Qui, Xue-zbao, Ni, Da-sbi, Liao, Hua-xln, Gao, Guang-zbong, Du, Yong-lin, Xu, Jian-kun, Wu, Yang-sben, Zbao, Jun-neng, Kong, Bi-xia, Wang, Zbeng-sbun, Zbang, Zbi-qiang, Sben, Hong-kai, Zbou, Ning
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral - analysis
Antigens
Antigens, Viral - analysis
China
Disease Reservoirs
Epidemics
Epidemiology
Etiology
Etiology and Pathogenesis
Fever
Hantavirus - immunology
Hemorrhagic Fever with Renal Syndrome - epidemiology
Hemorrhagic Fever with Renal Syndrome - immunology
Hemorrhagic Fever with Renal Syndrome - transmission
Humans
Lung - microbiology
Lungs
Medical sciences
Muridae - microbiology
Rats - microbiology
Reoviridae
Rodentia
Viruses
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Summary:Two strains of epidemic hemorrhagic fever (EHF) virus were isolated from the lung tissues of Apodemus agrarius mice that were captured in an area where EHF is endemic. The strains were isolated by passages in A. agrarius mice from a nonendemic area. Identification of the isolates by usual procedures was confirmed by repeated blind tests with coded sera. Contamination with certain known viruses such as reovirus, adenovirus (types 3 and 7), and other pathogens, such as murine typhus rickettsiae and Leptospira, which may be naturally present in wild rodents, appeared to have been ruled out. The antigen slides made from these isolates are in use in the specific diagnosis and seroepidemiologic studies of EHF. The first successful application is the serodiagnosis of a mild type of hemorrhagic fever that occurs with characteristic epidemiologic features in certain provinces of China.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/147.4.654