Bladder Cancer in a Low Risk Population: Results from the Adventist Health Study

A cohort study of bladder cancer was conducted in a population of California Seventh-day Adventists. Most Seventh-day Adventists use neither tobacco nor alcohol yet experience a large degree of variation in dietary habits. Therefore, diet and other lifestyle habits were evaluated in this unique popu...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 1991-02, Vol.133 (3), p.230-239
Main Authors: Mills, Paul K., Beeson, W.Lawrence, Phillips, Roland L., Fraser, Gary E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
bladder neoplasms
California - epidemiology
Carcinoma, Transitional Cell - epidemiology
Christianity
Cohort Studies
diet
Female
Food Preferences
Humans
Life Style
lifestyle
Male
Medical sciences
Nephrology. Urinary tract diseases
Religion and Sex
risk
Risk Factors
Smoking - epidemiology
Surveys and Questionnaires
Tumors of the urinary system
Urinary Bladder Neoplasms - epidemiology
Urinary tract. Prostate gland
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A cohort study of bladder cancer was conducted in a population of California Seventh-day Adventists. Most Seventh-day Adventists use neither tobacco nor alcohol yet experience a large degree of variation in dietary habits. Therefore, diet and other lifestyle habits were evaluated in this unique population. In 1976, 34,198 non-Hispanic white Seventh-day Adventists in California completed a detailed lifestyle questionnaire which induded a 51-Item food frequency section. This cohort was then followed until the end of 1982 during which time all newly diagnosed malignancies were detected. In order to evaluate the relation between several variables hypothesized to be associated with altered bladder cancer risk, age-, sex-, and smoking-adjusted relative risks (incidence rate ratios) were calculated using the method of Mantel-Haenszel adopted for person-time data. Multivariate analyses were conducted using the Cox Proportional Hazards Regression model. Between the return of the questionnaire and the end of follow-up, there were 52 histologically confirmed bladder cancers detected in the cohort. Increasing age, male gender, and a history of cigarette smoking were all significantly associated with increased bladder cancer risk. In addition, residence in a rural area was associated with significantly increased risk (relative risk (RR) = 1.80) as was high consumption of meat, poultry, and fish (RR = 2.57).
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a115867