Effect of soluble aminated beta-1,3-D-polyglucose on human monocytes: stimulation of cytokine and prostaglandin E2 production but not antigen-presenting function

Glucans are insoluble polymers of β‐1,3‐linked glucose derived from yeast cell walls that effectively activate macrophages. Recently, aminated derivatives of β‐1,3‐D‐polyglucose have been developed that are soluble but also activate murine macrophages. The current studies were undertaken to determin...

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Bibliographic Details
Published in:Journal of leukocyte biology 1991-04, Vol.49 (4), p.342-351
Main Authors: Doita, Minoru, Rasmussen, Lill‐Tove, Seljelid, Rolf, Lipsky, Peter E.
Format: Article
Language:English
Subjects:
beta-Glucans
Biological and medical sciences
Cells, Cultured
Cytokines - biosynthesis
Dinoprostone - biosynthesis
Dose-Response Relationship, Drug
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene Expression Regulation
Glucans - pharmacology
HLA Antigens - biosynthesis
Humans
Immunobiology
In Vitro Techniques
Indomethacin - pharmacology
interleukin 1
Interleukin-1 - biosynthesis
Lipopolysaccharides - pharmacology
Monocytes - metabolism
Monocytes, macrophages
Myeloid cells: ontogeny, maturation, markers, receptors
paraformaldehyde
Tumor Necrosis Factor-alpha - biosynthesis
tumor necrosis factor‐α
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Summary:Glucans are insoluble polymers of β‐1,3‐linked glucose derived from yeast cell walls that effectively activate macrophages. Recently, aminated derivatives of β‐1,3‐D‐polyglucose have been developed that are soluble but also activate murine macrophages. The current studies were undertaken to determine whether soluble aminated β‐1,3‐D‐polyglucose (AG) would also stimulate human monocytes. The AG employed contained
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.49.4.342