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Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes

Structure-function activity relationships of drugs that bind to certain membrane-associated receptors must take into account the local membrane bilayer environment where the binding event occurs. In this Perspective, we have reexamined a model used in the equilibrium dissociation constant determinat...

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Published in:	Journal of medicinal chemistry 1991-03, Vol.34 (3), p.869-877
Main Authors:	MASON, R. P, RHODES, D. G, HERBETTE, L. G
Format:	Article
Language:	English
Subjects:	Biological and medical sciences Cell Membrane - metabolism Chemical Phenomena Chemistry, Physical General pharmacology Kinetics lipid bilayers Lipid Bilayers - metabolism Medical sciences Membrane Lipids - metabolism Models, Molecular Molecular Structure Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships reviews Structure-Activity Relationship
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container_end_page	877
container_issue	3
container_start_page	869
container_title	Journal of medicinal chemistry
container_volume	34
creator	MASON, R. P RHODES, D. G HERBETTE, L. G
description	Structure-function activity relationships of drugs that bind to certain membrane-associated receptors must take into account the local membrane bilayer environment where the binding event occurs. In this Perspective, we have reexamined a model used in the equilibrium dissociation constant determination for certain lipid-soluble drugs based on recent experimental data describing the interaction of these drugs with the membrane bilayer.
doi_str_mv	10.1021/jm00107a001
format	article
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subjects	Biological and medical sciences Cell Membrane - metabolism Chemical Phenomena Chemistry, Physical General pharmacology Kinetics lipid bilayers Lipid Bilayers - metabolism Medical sciences Membrane Lipids - metabolism Models, Molecular Molecular Structure Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships reviews Structure-Activity Relationship
title	Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes
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