Cerebral venous thrombosis with plasminogen deficiency

We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We a...

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Bibliographic Details
Published in:Stroke (1970) 1991-03, Vol.22 (3), p.401-405
Main Authors: SCHUTTA, H. S, WILLIAMS, E. C, BARANSKI, B. G, SUTULA, T. P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain - pathology
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
Intracranial Embolism and Thrombosis - complications
Intracranial Embolism and Thrombosis - diagnosis
Magnetic Resonance Imaging
Male
Medical sciences
Plasminogen - deficiency
Platelet diseases and coagulopathies
Warfarin - therapeutic use
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Summary:We describe a patient with inherited plasminogen deficiency who developed extensive cerebral venous thrombosis. Several other conditions that might have contributed to a hypercoagulable state, including mild thrombocytosis, thyrotoxicosis, and a chronic inflammatory lung disorder, were present. We also discuss the evidence linking plasminogen deficiency with a thrombophilic state. The diagnosis of cerebral venous thrombosis in this case was readily established by nuclear magnetic resonance imaging, a technique that is ideally suited for the evaluation and follow-up of patients with this condition.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.22.3.401