Band keratopathy in MRL/l and MRL/n mice

To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/l, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp--lpr/lpr, C57BL/6J--lpr/lpr, and normal control strains. Eighty-seven percen...

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Bibliographic Details
Published in:Arthritis and rheumatism 1983-05, Vol.26 (5), p.645-652
Main Authors: Hoffman, R W, Yang, H K, Waggie, K S, Durham, J B, Burge, J R, Walker, S E
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - complications
Autoimmune Diseases - pathology
Calcium - blood
Corneal Diseases - etiology
Corneal Diseases - pathology
Creatinine - blood
Disease Models, Animal
Female
Male
Mice
Mice, Inbred Strains - genetics
Parathyroid Hormone - blood
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Summary:To define ocular abnormalities in mice with autoimmune disease, we performed biomicroscopic examinations and examined ocular tissue in MRL/l, MRL/n, NZB, NZB/NZW, and Palmerston North mice. Results were compared with MRL/Mp--lpr/lpr, C57BL/6J--lpr/lpr, and normal control strains. Eighty-seven percent of MRL/l and MRL/n mice had typical band keratopathy; this was confirmed by histologic examination. Posterior uveitis was found in 35% of adult MRL/l mice. MRL substrains are potentially important models of ocular disease.
ISSN:0004-3591