The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

The floor plate is a set of epithelial cells present in the ventral midline of the neural tube in vertebrates that seems to have an important role in the developmental patterning of central nervous system fibre pathways, and arrangements of specific neurons. The floor plate arises from dorsal ectode...

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Bibliographic Details
Published in:Nature (London) 1991-03, Vol.350 (6316), p.339-341
Main Authors: Hatta, Kohei, Kimmel, Charles B, Ho, Robert K, Walker, Charline
Format: Article
Language:English
Subjects:
Animals
Aquatic life
Biological and medical sciences
Brain - anatomy & histology
Brain - cytology
Brain - embryology
Central nervous system
Cyclops
Danio rerio
Embryo, Nonmammalian - physiology
Embryology: invertebrates and vertebrates. Teratology
Embryos
Fish
Freshwater
Fundamental and applied biological sciences. Psychology
Marine biology
Mutation
Nerve Fibers - ultrastructure
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Zebrafish - genetics
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Summary:The floor plate is a set of epithelial cells present in the ventral midline of the neural tube in vertebrates that seems to have an important role in the developmental patterning of central nervous system fibre pathways, and arrangements of specific neurons. The floor plate arises from dorsal ectodermal cells closely associated with the mesoderm that forms notochord, and it may depend on interactions from the notochord for its specification. To learn the nature of these interactions we have analysed mutations in zebrafish (Brachydanio rerio). We report here that in wild-type embryos the floor plate develops as a simply organized single cell row, but that its development fails in embryos bearing the newly discovered zygotic lethal 'cyclops' mutation, cyc-1(b16). Mosaic analysis establishes that cyc-1 blocks floor plate development autonomously and reveals the presence of homeogenetic induction between floor plate cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/350339a0