BUTALACTIN, A NEW BUTANOLIDE ANTIBIOTIC: TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL ACTIVITY

Butalactin, [2-(4', 5'-epoxy-hex-2'(E)-en)oyl-2-hydroxy-3-hydroxymethyl-2, 3-(Z)-butanolide] is a new antibiotic produced by Streptomyces sp. HIL Y-86, 36923. Taxonomically, the producing organism most closely resembles Streptomyces corchorusii. The strain also produces cineromycin B....

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Bibliographic Details
Published in:Journal of antibiotics 1991/02/25, Vol.44(2), pp.225-231
Main Authors: FRANCO, CHRISTOPHER M. M., BORDE, URMILA P., VIJAYAKUMAR, E. K. S., CHATTERJEE, SUGATA, BLUMBACH, JURGEN, GANGULI, BIMAL N.
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - isolation & purification
4-Butyrolactone - metabolism
4-Butyrolactone - pharmacology
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacteria - drug effects
Biological and medical sciences
Chromatography, Thin Layer
Culture Media
Fermentation
Fundamental and applied biological sciences. Psychology
Microbiology
Microscopy, Electron
Soil Microbiology
Spores, Bacterial - ultrastructure
Streptomyces - classification
Streptomyces - drug effects
Streptomyces - metabolism
Streptomyces - ultrastructure
Streptomycin - biosynthesis
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Summary:Butalactin, [2-(4', 5'-epoxy-hex-2'(E)-en)oyl-2-hydroxy-3-hydroxymethyl-2, 3-(Z)-butanolide] is a new antibiotic produced by Streptomyces sp. HIL Y-86, 36923. Taxonomically, the producing organism most closely resembles Streptomyces corchorusii. The strain also produces cineromycin B. Though butalactin is structurally related to 'signal molecules' such as A-factor, the anthracycline inducing factors and the virginiae butanolides, it does not show inducing activity for antibiotic production or aerial mycelium formation in the indicator strain. Butalactin possesses a weak antibiotic activity against Gram-positive and Gram-negative bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.44.225