Bactericidal and Opsonic Activity of Ascitic Fluid from Cirrhotic and Noncirrhotic Patients

Cirrhotic patients with ascites are highly susceptible to spontaneous bacterial peritonitis. Patients with ascites due to causes other than cirrhosis very seldom develop peritonitis. The antibacterial activity of these ascitic fluids is not known. The present study was undertaken to evaluate the bac...

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Bibliographic Details
Published in:The Journal of infectious diseases 1983-06, Vol.147 (6), p.1011-1017
Main Authors: Akalin, H. Erdal, Laleli, Yahya, Telatar, Hasan
Format: Article
Language:English
Subjects:
Antibacterials
Ascites
Ascitic Fluid
Ascitic Fluid - analysis
Ascitic Fluid - immunology
Bacteria
Bacterial Infections - etiology
Bacterial Infections - immunology
Cirrhosis
Complement System Proteins - analysis
Constrictive pericarditis
Host Susceptibility and Defense
Humans
Immunoglobulins
Immunoglobulins - analysis
Leukocytes
Liver Cirrhosis - complications
Liver Cirrhosis - immunology
Opsonin Proteins - physiology
Peritonitis
Peritonitis - etiology
Phagocytosis
Statistical significance
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Summary:Cirrhotic patients with ascites are highly susceptible to spontaneous bacterial peritonitis. Patients with ascites due to causes other than cirrhosis very seldom develop peritonitis. The antibacterial activity of these ascitic fluids is not known. The present study was undertaken to evaluate the bactericidal and opsonic activity in ascitic fluid from patients with and without cirrhosis and in normal (nonascitic) peritoneal fluid. Normal peritoneal fluids of 20 control subjects and ascitic fluids of 22 patients with noncirrhotic ascites all had normal bactericidal activity. The bactericidal activity of ascitic fluid was diminished in all 25 patients with cirrhosis (P
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/147.6.1011