In vitro release of endogenous monoamines and amino acids from several CNS regions of the rat

The in vitro release of endogenous norepinephrine (NE), dopamine (DA), serotonin (5-HT), GABA, glutamate (GLU), aspartate (ASP), glycine (GLY), taurine (TAU) and alanine (ALA) from superfused slices of cerebral cortex (CTX), striatum (STR), hippocampus (HIP), hypothalamus (HYPO), midbrain (MB), thal...

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Bibliographic Details
Published in:Neurochemical research 1983-02, Vol.8 (2), p.245-257
Main Authors: McBride, W J, Flint, R S, Ciancone, M T, Murphy, J M
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Aspartic Acid - metabolism
Biogenic Amines - metabolism
Calcium - metabolism
Central Nervous System - metabolism
Dopamine - metabolism
gamma-Aminobutyric Acid - metabolism
Glutamates - metabolism
In Vitro Techniques
Male
Norepinephrine - metabolism
Potassium - pharmacology
Rats
Rats, Inbred Strains
Serotonin - metabolism
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Summary:The in vitro release of endogenous norepinephrine (NE), dopamine (DA), serotonin (5-HT), GABA, glutamate (GLU), aspartate (ASP), glycine (GLY), taurine (TAU) and alanine (ALA) from superfused slices of cerebral cortex (CTX), striatum (STR), hippocampus (HIP), hypothalamus (HYPO), midbrain (MB), thalamus (THAL), nucleus accumbens (ACC), pons-medulla (PM) and spinal cord (SC) was studied. The data (a) do not support a transmitter for ALA and TAU in the CNS; (b) support a major transmitter function for GLY only in the PM and SC; and (c) support a transmitter role for GABA, GLU, NE, DA and 5-HT in the CNS regions examined (with the exception of GABA and GLU in the ACC where no data were obtained).
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00963924