Intermolecular Interactions in Collagen Self-Assembly as Revealed by Fourier Transform Infrared Spectroscopy

When a solution of collagen molecules, at neutral pH and moderate ionic strength, is warmed from 4° to 30° C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aque...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-06, Vol.220 (4603), p.1288-1290
Main Authors: Jakobsen, R. J., Brown, L. L., Hutson, T. B., Fink, D. J., Veis, A.
Format: Article
Language:English
Subjects:
Amides
Animals
Collagen
Collagen - metabolism
Collagens
Connective Tissue - metabolism
Fourier transform spectroscopy
Fourier transformations
Infrared spectroscopy
Infrared spectrum
Molecular biology
Molecular interactions
Rats
Self assembly
Solar fibrils
Spectral bands
Spectrophotometry, Infrared
Temperature
Temperature gradients
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Summary:When a solution of collagen molecules, at neutral pH and moderate ionic strength, is warmed from 4° to 30° C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aqueous media and in real time, by Fourier transform infrared spectroscopic techniques. Tentative assignments of observed spectral bands are given.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6857249