Thixotropy of Different Concentrations of Microcrystalline Cellulose:Sodium Carboxymethyl Cellulose Gels

An extensive study is made of the rheologic behavior of microcrystalline cellulose:sodium carboxymethyl cellulose gels at six different concentrations (between 1 and 2.5% by weight). The thixotropy of these gels was analyzed in terms of agitation time, the duration of storage, concentration, and tem...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1991-01, Vol.80 (1), p.75-79
Main Authors: Dolz-Planas, M., Roldan-Garcia, C., Herraez-Dominguez, J.V., Belda-Maximino, R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carboxymethylcellulose Sodium - chemistry
Cellulose - chemistry
Chemical Phenomena
Chemistry, Physical
Gels
General pharmacology
Medical sciences
Models, Chemical
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Rheology
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Summary:An extensive study is made of the rheologic behavior of microcrystalline cellulose:sodium carboxymethyl cellulose gels at six different concentrations (between 1 and 2.5% by weight). The thixotropy of these gels was analyzed in terms of agitation time, the duration of storage, concentration, and temperature; a semiempirical function was thus obtained providing thixotropic area as a function of these variables. The instantaneous variation rate in thixotropic area was defined, providing a better understanding of the rate of structural breakdown. Also, it is shown that after 5min of agitation, the variation rate becomes negligible (~0.7% of the initial value); this result is practically independent of the remaining variables.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600800119