Epidural infusion of diamorphine with bupivacaine in labour : a comparison with fentanyl and bupivacaine

We have compared the analgesic effects of three epidural infusions in a randomised, double-blind study of 61 mothers in labour. An initial dose of bupivacaine 0.5% 8 ml was followed by either bupivacaine 0.125%, bupivacaine 0.125% with diamorphine 0.0025% or bupivacaine 0.125% with fentanyl 0.0002%....

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Bibliographic Details
Published in:Anaesthesia 1991-03, Vol.46 (3), p.169-173
Main Authors: ENEVER, G. R, NOBLE, H. A, KOLDITZ, D, VALENTINE, S, THOMAS, T. A
Format: Article
Language:English
Subjects:
Analgesia, Epidural - adverse effects
Analgesia, Obstetrical - adverse effects
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Bupivacaine - administration & dosage
Double-Blind Method
Female
Fentanyl - administration & dosage
Heroin - administration & dosage
Humans
Infusions, Parenteral
Labor, Obstetric
Medical sciences
Neuropharmacology
Pain Measurement
Pharmacology. Drug treatments
Pregnancy
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Summary:We have compared the analgesic effects of three epidural infusions in a randomised, double-blind study of 61 mothers in labour. An initial dose of bupivacaine 0.5% 8 ml was followed by either bupivacaine 0.125%, bupivacaine 0.125% with diamorphine 0.0025% or bupivacaine 0.125% with fentanyl 0.0002%. All infusions were run at a rate of 7.5 ml/hour. Analgesia was significantly better in both the groups receiving opioids. Diamorphine was shown to be the more effective supplement to bupivacaine. The 5% incidence of pruritus in the opioid groups was less than that reported by earlier authors.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1991.tb09401.x