Use of adjuvant containing mycobacterial cell-wall skeleton, monophosphoryl lipid A, and squalane in malaria circumsporozoite protein vaccine

Human immune responses to modern synthetic and recombinant peptide vaccines administered with the standard adjuvant, aluminum hydroxide, tend to be poor, hence the search for better adjuvants. Antibody responses to a Plasmodium falciparum circumsporozoite (CS) protein vaccine, R32NS181, administered...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-04, Vol.337 (8748), p.998-1001
Main Authors: Rickman, L.S, Wistar, R, Hoffman, S.L, Gordon, D.M, Krzych, U, Egan, J.E, Chulay, J.D, Gross, M, Hollingdale, M.R
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic - administration & dosage
Adult
Aluminum
Aluminum hydroxide
Animals
Antibodies
Antibodies, Protozoan - analysis
Antibody Affinity - drug effects
Applied microbiology
Avidity
Biological and medical sciences
Cell Wall - microbiology
Circumsporozoite protein
Enzyme-linked immunosorbent assay
Fundamental and applied biological sciences. Psychology
Hepatoma
Human behavior
Humans
Immune response
Immunity (Disease)
Immunogenicity
Immunoglobulin G - analysis
Lipid A
Lipid A - administration & dosage
Lipid A - analogs & derivatives
Lipids
Malaria
Malaria Vaccines
Male
Medical research
Microbiology
Monophosphoryl lipid A
Mycobacterium - cytology
Plasmodium falciparum
Plasmodium falciparum - immunology
Proteins
Protozoan Vaccines - administration & dosage
Protozoan Vaccines - adverse effects
Protozoan Vaccines - immunology
Recombinant Fusion Proteins
Sporozoites
Squalene - administration & dosage
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - adverse effects
Vaccines, Synthetic - immunology
Vector-borne diseases
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Summary:Human immune responses to modern synthetic and recombinant peptide vaccines administered with the standard adjuvant, aluminum hydroxide, tend to be poor, hence the search for better adjuvants. Antibody responses to a Plasmodium falciparum circumsporozoite (CS) protein vaccine, R32NS181, administered with an adjuvant containing cell-wall skeleton of mycobacteria and monophosphoryl lipid A in squalane (MPL/CWS) have been compared to responses to the same immunogen adminstered with aluminum hydroxide. 2 weeks after the third dose the following indices were greater in the 5 patients who received MPL/CWS than in controls (p
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)92659-P