Comparative effects of a repeated dose regime of diazepam and buspirone on subjective ratings, psychological tests and the EEG

Two doses of buspirone (5 and 10 mg tds), 1 dose of diazepam (5 mg tds) and placebo were administered to 8 normal subjects for a period of 8 days. Each subject received each drug in a balanced order with a minimum interval of 1 week between courses. Psychotropic effects were assessed with a battery...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1983-01, Vol.24 (4), p.463-467
Main Authors: Bond, A, Lader, M, Shrotriya, R
Format: Article
Language:English
Subjects:
Adult
Anti-Anxiety Agents - pharmacology
Buspirone
Diazepam - pharmacology
Double-Blind Method
Electroencephalography
Emotions - drug effects
Evoked Potentials - drug effects
Female
Humans
Male
Middle Aged
Psychological Tests
Psychomotor Performance - drug effects
Pyrimidines - pharmacology
Reaction Time - drug effects
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Summary:Two doses of buspirone (5 and 10 mg tds), 1 dose of diazepam (5 mg tds) and placebo were administered to 8 normal subjects for a period of 8 days. Each subject received each drug in a balanced order with a minimum interval of 1 week between courses. Psychotropic effects were assessed with a battery of physiological, psychomotor and subjective tests on the first, third and last days of treatment both before the first daily dose and at 1 h and 3 h after it. Diazepam showed a characteristic profile of action producing EEG changes and psychological impairment after a single dose which were still present after a week's treatment. Such effects were minimal after buspirone. Both drugs increased subjective ratings of drowsiness but these feelings tended to decrease after a week's treatment on the clinical doses. Buspirone (10 mg tds) produced some unpleasant side-effects initially but tolerance to these invariably developed after 3 days treatment.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00609887