Hepatitis B Virus Infection in Cultured Human Lymphoblastoid Cells

Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4611), p.667-669
Main Authors: Romet-Lemonne, Jean-Loup, McLane, Mary Frances, Elfassi, Emile, Haseltine, William A., Azocar, José, Essex, Myron
Format: Article
Language:English
Subjects:
B lymphocytes
Biological and medical sciences
Bone marrow cells
Cell culture techniques
Cell lines
Cells, Cultured
Cellular immunity
Cultured cells
Fundamental and applied biological sciences. Psychology
Hep G2 cells
Hepatitis
Hepatitis antigens
Hepatitis B - microbiology
Hepatitis B - pathology
Hepatitis B Surface Antigens - immunology
Hepatitis B virus
Hepatitis B virus - growth & development
Hepatocytes
Humans
Liver - pathology
Lymphocytes - microbiology
Lymphocytes - pathology
Male
Microbiology
Middle Aged
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
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Summary:Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6867736