The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts

The decreased collagen content in aging skin could be a consequence of decreased synthesis or increased degradation. The possibility that decreased synthesis of collagen results from decreased synthesis of mRNAs for Type I collagen, the major collagen in skin, was investigated by assessing the stead...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gerontology (Kirkwood) 1991-05, Vol.46 (3), p.B122-B124
Main Author: Furth, J J
Format: Article
Language:English
Subjects:
Aging & longevity
Aging - metabolism
Cell Survival
Cells, Cultured
Collagen - genetics
Fibroblasts - metabolism
Humans
RNA, Messenger - analysis
Skin
Skin - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c264t-602559b1665d2f027a1c6649ef5e98daa2824eb99034c615a88a4cce5fca98f93
cites
container_end_page B124
container_issue 3
container_start_page B122
container_title Journal of gerontology (Kirkwood)
container_volume 46
creator Furth, J J
description The decreased collagen content in aging skin could be a consequence of decreased synthesis or increased degradation. The possibility that decreased synthesis of collagen results from decreased synthesis of mRNAs for Type I collagen, the major collagen in skin, was investigated by assessing the steady-state levels of alpha 1(I) and alpha 2(I) collagen mRNAs in actively proliferating and senescent WI-38 fibroblasts. The levels of both alpha 1(I) mRNA and alpha 2(I) mRNA were significantly lower in senescent fibroblasts, suggesting that one factor contributing to the decreased collagen content of aging skin may be decreased synthesis of these collagen mRNAs by senescent fibroblasts. Both mRNAs were reduced to the same extent, suggesting that coordinate regulation of the two Type I collagen genes is maintained in senescent fibroblasts.
doi_str_mv 10.1093/geronj/46.3.B122
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80556620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1301125225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c264t-602559b1665d2f027a1c6649ef5e98daa2824eb99034c615a88a4cce5fca98f93</originalsourceid><addsrcrecordid>eNp1kUtLw0AUhQdRaq3u3QiDgrvUO3ceTZa1-AJRkLoeJpOb2pImdSYR-u-NtLgQXN3Ndw7n8jF2LmAsIJM3CwpNvbpRZizHtwLxgA1RSpFIifKQDQEQE6EQj9lJjCsAgQbMgA0QJKAxQzaffxCPLblim8TWtcQr-qIq8qbk7XZD_In7pqrcgmq-fnuZcheIByo6TwVf1jxSTdFT3fJymYcmr1xs4yk7Kl0V6Wx_R-z9_m4-e0yeXx-eZtPnxKNRbWIAtc5yYYwusAScOOGNURmVmrK0cA5TVJRnGUjljdAuTZ3ynnTpXZaWmRyx613vJjSfHcXWrpf9mH5uTU0XbQpaG9P_OmKXf8BV04W632YRUmlggqqHrv6DhAQhUCPqnoId5UMTY6DSbsJy7cLWCrA_TuzOiVXGSvvjpI9c7Iu7fE3Fb2AvQX4DyqqGzg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1301125225</pqid></control><display><type>article</type><title>The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts</title><source>Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025</source><creator>Furth, J J</creator><creatorcontrib>Furth, J J</creatorcontrib><description>The decreased collagen content in aging skin could be a consequence of decreased synthesis or increased degradation. The possibility that decreased synthesis of collagen results from decreased synthesis of mRNAs for Type I collagen, the major collagen in skin, was investigated by assessing the steady-state levels of alpha 1(I) and alpha 2(I) collagen mRNAs in actively proliferating and senescent WI-38 fibroblasts. The levels of both alpha 1(I) mRNA and alpha 2(I) mRNA were significantly lower in senescent fibroblasts, suggesting that one factor contributing to the decreased collagen content of aging skin may be decreased synthesis of these collagen mRNAs by senescent fibroblasts. Both mRNAs were reduced to the same extent, suggesting that coordinate regulation of the two Type I collagen genes is maintained in senescent fibroblasts.</description><identifier>ISSN: 0022-1422</identifier><identifier>EISSN: 2331-3323</identifier><identifier>DOI: 10.1093/geronj/46.3.B122</identifier><identifier>PMID: 2030266</identifier><language>eng</language><publisher>United States: Gerontological Society</publisher><subject>Aging &amp; longevity ; Aging - metabolism ; Cell Survival ; Cells, Cultured ; Collagen - genetics ; Fibroblasts - metabolism ; Humans ; RNA, Messenger - analysis ; Skin ; Skin - metabolism</subject><ispartof>Journal of gerontology (Kirkwood), 1991-05, Vol.46 (3), p.B122-B124</ispartof><rights>Copyright Gerontological Society of America, Incorporated May 1991</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c264t-602559b1665d2f027a1c6649ef5e98daa2824eb99034c615a88a4cce5fca98f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2030266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furth, J J</creatorcontrib><title>The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts</title><title>Journal of gerontology (Kirkwood)</title><addtitle>J Gerontol</addtitle><description>The decreased collagen content in aging skin could be a consequence of decreased synthesis or increased degradation. The possibility that decreased synthesis of collagen results from decreased synthesis of mRNAs for Type I collagen, the major collagen in skin, was investigated by assessing the steady-state levels of alpha 1(I) and alpha 2(I) collagen mRNAs in actively proliferating and senescent WI-38 fibroblasts. The levels of both alpha 1(I) mRNA and alpha 2(I) mRNA were significantly lower in senescent fibroblasts, suggesting that one factor contributing to the decreased collagen content of aging skin may be decreased synthesis of these collagen mRNAs by senescent fibroblasts. Both mRNAs were reduced to the same extent, suggesting that coordinate regulation of the two Type I collagen genes is maintained in senescent fibroblasts.</description><subject>Aging &amp; longevity</subject><subject>Aging - metabolism</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Collagen - genetics</subject><subject>Fibroblasts - metabolism</subject><subject>Humans</subject><subject>RNA, Messenger - analysis</subject><subject>Skin</subject><subject>Skin - metabolism</subject><issn>0022-1422</issn><issn>2331-3323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLw0AUhQdRaq3u3QiDgrvUO3ceTZa1-AJRkLoeJpOb2pImdSYR-u-NtLgQXN3Ndw7n8jF2LmAsIJM3CwpNvbpRZizHtwLxgA1RSpFIifKQDQEQE6EQj9lJjCsAgQbMgA0QJKAxQzaffxCPLblim8TWtcQr-qIq8qbk7XZD_In7pqrcgmq-fnuZcheIByo6TwVf1jxSTdFT3fJymYcmr1xs4yk7Kl0V6Wx_R-z9_m4-e0yeXx-eZtPnxKNRbWIAtc5yYYwusAScOOGNURmVmrK0cA5TVJRnGUjljdAuTZ3ynnTpXZaWmRyx613vJjSfHcXWrpf9mH5uTU0XbQpaG9P_OmKXf8BV04W632YRUmlggqqHrv6DhAQhUCPqnoId5UMTY6DSbsJy7cLWCrA_TuzOiVXGSvvjpI9c7Iu7fE3Fb2AvQX4DyqqGzg</recordid><startdate>199105</startdate><enddate>199105</enddate><creator>Furth, J J</creator><general>Gerontological Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOIBA</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>199105</creationdate><title>The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts</title><author>Furth, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c264t-602559b1665d2f027a1c6649ef5e98daa2824eb99034c615a88a4cce5fca98f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Aging &amp; longevity</topic><topic>Aging - metabolism</topic><topic>Cell Survival</topic><topic>Cells, Cultured</topic><topic>Collagen - genetics</topic><topic>Fibroblasts - metabolism</topic><topic>Humans</topic><topic>RNA, Messenger - analysis</topic><topic>Skin</topic><topic>Skin - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Furth, J J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 29</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access &amp; Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access &amp; Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access &amp; Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access &amp; Build (Plan A) - APAC</collection><collection>Primary Sources Access &amp; Build (Plan A) - Canada</collection><collection>Primary Sources Access &amp; Build (Plan A) - West</collection><collection>Primary Sources Access &amp; Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access &amp; Build (Plan A) - Midwest</collection><collection>Primary Sources Access &amp; Build (Plan A) - North Central</collection><collection>Primary Sources Access &amp; Build (Plan A) - Northeast</collection><collection>Primary Sources Access &amp; Build (Plan A) - South Central</collection><collection>Primary Sources Access &amp; Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gerontology (Kirkwood)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furth, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts</atitle><jtitle>Journal of gerontology (Kirkwood)</jtitle><addtitle>J Gerontol</addtitle><date>1991-05</date><risdate>1991</risdate><volume>46</volume><issue>3</issue><spage>B122</spage><epage>B124</epage><pages>B122-B124</pages><issn>0022-1422</issn><eissn>2331-3323</eissn><abstract>The decreased collagen content in aging skin could be a consequence of decreased synthesis or increased degradation. The possibility that decreased synthesis of collagen results from decreased synthesis of mRNAs for Type I collagen, the major collagen in skin, was investigated by assessing the steady-state levels of alpha 1(I) and alpha 2(I) collagen mRNAs in actively proliferating and senescent WI-38 fibroblasts. The levels of both alpha 1(I) mRNA and alpha 2(I) mRNA were significantly lower in senescent fibroblasts, suggesting that one factor contributing to the decreased collagen content of aging skin may be decreased synthesis of these collagen mRNAs by senescent fibroblasts. Both mRNAs were reduced to the same extent, suggesting that coordinate regulation of the two Type I collagen genes is maintained in senescent fibroblasts.</abstract><cop>United States</cop><pub>Gerontological Society</pub><pmid>2030266</pmid><doi>10.1093/geronj/46.3.B122</doi></addata></record>
fulltext fulltext
identifier ISSN: 0022-1422
ispartof Journal of gerontology (Kirkwood), 1991-05, Vol.46 (3), p.B122-B124
issn 0022-1422
2331-3323
language eng
recordid cdi_proquest_miscellaneous_80556620
source Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects Aging & longevity
Aging - metabolism
Cell Survival
Cells, Cultured
Collagen - genetics
Fibroblasts - metabolism
Humans
RNA, Messenger - analysis
Skin
Skin - metabolism
title The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T19%3A51%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20steady-state%20levels%20of%20type%20I%20collagen%20mRNA%20are%20reduced%20in%20senescent%20fibroblasts&rft.jtitle=Journal%20of%20gerontology%20(Kirkwood)&rft.au=Furth,%20J%20J&rft.date=1991-05&rft.volume=46&rft.issue=3&rft.spage=B122&rft.epage=B124&rft.pages=B122-B124&rft.issn=0022-1422&rft.eissn=2331-3323&rft_id=info:doi/10.1093/geronj/46.3.B122&rft_dat=%3Cproquest_cross%3E1301125225%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c264t-602559b1665d2f027a1c6649ef5e98daa2824eb99034c615a88a4cce5fca98f93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1301125225&rft_id=info:pmid/2030266&rfr_iscdi=true