UPTAKE OF ENFLURANE: A STUDY OF THE VARIABILITY BETWEEN PATIENTS

Variability in the uptake of enflurane has been studied using a computer-controlled “overpressure” induction technique in 23 paediatric patients. The administration of enflurane was feedback-controlled and its uptake measured using a closed anaesthesia delivery system with the end-tidal concentratio...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1983-07, Vol.55 (7), p.595-601
Main Authors: WESTENSKOW, D.R., JORDAN, W.S., HAYES, J.K.
Format: Article
Language:English
Subjects:
Adolescent
Anesthesia, General
Blood Pressure
Child
Child, Preschool
Enflurane - metabolism
Female
Heart Rate
Humans
Male
Oxygen Consumption
Time Factors
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Summary:Variability in the uptake of enflurane has been studied using a computer-controlled “overpressure” induction technique in 23 paediatric patients. The administration of enflurane was feedback-controlled and its uptake measured using a closed anaesthesia delivery system with the end-tidal concentration held constant at 2.0%. The standard deviation in uptake was greater than 28% of the average uptake during the first 60 min of enflurane anaesthesia. The uptake at 60min ranged from 5.7 to 16.2ml min−1 m−2. The variability in enflurane uptake between patients was best minimized by normalizing the patient’s uptake according to body surface area. Although the average total volume of enflurane calculated according to a model compared well with the average total volume given in our study, the variation in uptake between patients indicated that a single model cannot be used to deliver anaesthesia to a varied patient population. The system described in this paper demonstrates the feasibility of using feedback control of fresh gas delivery for the automatic control of an “overpressure” induction technique.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/55.7.595