Penetration and effect of topically applied dimethylsulfoxide or indomethacin on adjuvant arthritis in the rat

The present study, using 14C‐DMSO, established the systemic and local load and distribution of topically applied DMSO in adjuvant arthritic rats. Under equivalent conditions, the antiinflammatory effects (systemic and local) of topical DMSO treatments were compared with a topical treatment of a cont...

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Bibliographic Details
Published in:Arthritis and rheumatism 1983-07, Vol.26 (7), p.861-865
Main Authors: Francis, Marion D., Horn, Patricia A., Mccreary, Lionel D.
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Arthritis - drug therapy
Arthritis, Experimental - drug therapy
Body Weight
Carbon Radioisotopes
Dimethyl Sulfoxide - administration & dosage
Dimethyl Sulfoxide - therapeutic use
Indomethacin - administration & dosage
Indomethacin - therapeutic use
Inflammation - drug therapy
Rats
Rats, Inbred Strains
Time Factors
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Summary:The present study, using 14C‐DMSO, established the systemic and local load and distribution of topically applied DMSO in adjuvant arthritic rats. Under equivalent conditions, the antiinflammatory effects (systemic and local) of topical DMSO treatments were compared with a topical treatment of a control vehicle or of indomethacin, a known effective antiinflammatory agent. No significant systemic or local antiinflammatory effect of topical DMSO was seen in the adjuvant arthritic rats. Indomethacin, applied topically, had a significant systemic antiinflammatory effect; however, no significant local antiinflammatory effect of indomethacin was observed.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780260707