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(Benzoylphenyl)piperidines: a new class of immunomodulators

A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety...

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Published in:	Journal of medicinal chemistry 1991-05, Vol.34 (5), p.1545-1552
Main Authors:	Bellamy, Francois D, Chazan, Jean B, Dodey, Pierre, Dutartre, Patrick, Ou, Khan, Pascal, Marc, Robin, Jacques
Format:	Article
Language:	English
Subjects:	Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - pharmacology Animals Cell Division - drug effects Chemical Phenomena Chemistry Exact sciences and technology Lymphocyte Activation - drug effects Mice Mice, Inbred DBA Mice, Nude Mitogens - antagonists & inhibitors Noncondensed benzenic compounds Organic chemistry Piperidines - chemical synthesis Piperidines - pharmacology Preparations and properties Structure-Activity Relationship T-Lymphocytes - drug effects
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container_end_page	1552
container_issue	5
container_start_page	1545
container_title	Journal of medicinal chemistry
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creator	Bellamy, Francois D Chazan, Jean B Dodey, Pierre Dutartre, Patrick Ou, Khan Pascal, Marc Robin, Jacques
description	A series of (benzoylphenyl)piperidines has been synthesized and evaluated for activity as immunomodulators. Several of these compounds show good activity in primary screening on the basis of the lymphocytes mitogenic response to Con A, PHA, and PWM. A chloro group in position 4 of the benzoyl moiety as well as an amino group (or a carbamate derivative) para to the piperidine nucleus seems to be essential for activity. The depicted compounds may be considered as the first examples of a new series of immunomodulators.
doi_str_mv	10.1021/jm00109a004
format	article
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subjects	Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - pharmacology Animals Cell Division - drug effects Chemical Phenomena Chemistry Exact sciences and technology Lymphocyte Activation - drug effects Mice Mice, Inbred DBA Mice, Nude Mitogens - antagonists & inhibitors Noncondensed benzenic compounds Organic chemistry Piperidines - chemical synthesis Piperidines - pharmacology Preparations and properties Structure-Activity Relationship T-Lymphocytes - drug effects
title	(Benzoylphenyl)piperidines: a new class of immunomodulators
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