O-Glycosylation in Saccharomyces cerevisiae is initiated at the endoplasmic reticulum

The first mannose of O-linked oligomannose chains in S. cerevisiae is transferred to Ser/Thr residues via dolichylphosphate mannose. Only this reaction (and not the subsequent reactions requiring GDP-Man) proceeds at the endoplasmic reticulum.

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Bibliographic Details
Published in:FEBS letters 1983-07, Vol.158 (2), p.335-338
Main Authors: Haselbeck, Anton, Tanner, Widmar
Format: Article
Language:English
Subjects:
Biological Transport
Chemical Phenomena
Chemistry
Dolichylphosphate
Endoplasmic Reticulum - metabolism
Glycoprotein
Glycoproteins - metabolism
Intracellular transport
Mannose - metabolism
Mutation
O-Glycosylation
Oligosaccharides - biosynthesis
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
sec- mutant
Temperature
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Description
Summary:The first mannose of O-linked oligomannose chains in S. cerevisiae is transferred to Ser/Thr residues via dolichylphosphate mannose. Only this reaction (and not the subsequent reactions requiring GDP-Man) proceeds at the endoplasmic reticulum.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(83)80608-5