The neuromuscular blocking effect of Org 9426 : a new intermediately-acting steroidal non-depolarising muscle relaxant in man

Org 9426, a new steroidal non-depolarising muscle relaxant, which is stable in solution, was studied in 30 anaesthetised (thiopentone, fentanyl, nitrous oxide) male patients, ASA 1 or 2. A dose-response curve for Org 9426 was constructed and the ED90, mean (SD), was found to be 0.36 (0.031) mg/kg. T...

Full description

Saved in:
Bibliographic Details
Published in:Anaesthesia 1991-05, Vol.46 (5), p.341-343
Main Authors: BOOIJ, L. H. D. J, KNAPE, H. T. A
Format: Article
Language:English
Subjects:
Adult
Androstanols - pharmacology
Anesthesia, General
Anesthesia, Intravenous
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Dose-Response Relationship, Drug
Humans
Male
Medical sciences
Middle Aged
Muscle Contraction - drug effects
Neuromuscular Blocking Agents
Neuropharmacology
Pharmacology. Drug treatments
Rocuronium
Time Factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Org 9426, a new steroidal non-depolarising muscle relaxant, which is stable in solution, was studied in 30 anaesthetised (thiopentone, fentanyl, nitrous oxide) male patients, ASA 1 or 2. A dose-response curve for Org 9426 was constructed and the ED90, mean (SD), was found to be 0.36 (0.031) mg/kg. The onset of action was 3.8 (1.8) minutes, the clinical duration 17.4 (3.2) minutes, the total duration of action 31.9 (6.2) minutes and the recovery time 9.96 (3.2) minutes. No signs of histamine release or cardiovascular effects were observed. Org 9426 thus has a faster onset of action than vecuronium bromide or atracurium dibesylate.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1991.tb09539.x