Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma

A 22-year-old female with a thymic carcinoma is reported. The tumor was refractory to both chemotherapy and irradiation. The patient died with an aggressive clinical course. Cytogenetic study showed that the tumor cells had a chromosome translocation, t(15;19)(q15;p13), which was not identified prev...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1991-06, Vol.51 (12), p.3327-3328
Main Authors: KUBONISHI, I, TAKEHARA, N, IWATA, J, SONOBE, H, OHTSUKI, Y, ABE, T, MIYOSHI, I
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
chromosome 15
chromosome 19
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 19
Female
Humans
Karyotyping
Mediastinal Neoplasms - diagnosis
Mediastinal Neoplasms - genetics
Mediastinal Neoplasms - pathology
Medical sciences
Pharmacology. Drug treatments
Thymus Neoplasms - diagnosis
Thymus Neoplasms - genetics
Thymus Neoplasms - pathology
translocation
Translocation, Genetic
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Summary:A 22-year-old female with a thymic carcinoma is reported. The tumor was refractory to both chemotherapy and irradiation. The patient died with an aggressive clinical course. Cytogenetic study showed that the tumor cells had a chromosome translocation, t(15;19)(q15;p13), which was not identified previously in human cancer.
ISSN:0008-5472
1538-7445