CLINICAL EVALUATION OF SULTAMICILLIN IN LOWER RESPIRATORY TRACT INFECTIONS

• Published in: Japanese journal of antibiotics 1991/02/25, Vol.44(2), pp.150-159
• Main Authors: ISHIBASHI, TSUNEO, TAKAMOTO, MASAHIRO, SHINODA, ATSUSHI, YOSHIDA, MINORU, ICHIKAWA, YOICHIRO, KIDO, MASAMITSU, NINOMIYA, KIYOSHI, KITAHARA, YASUHISA, MIYAZAKI, NOBUYOSHI, MATSUZAKI, YOSHIKAZU, TSURUTANI, HIDETO, YAMADA, HOZUMI, KIYA, TAKAKAZU, KOGA, HIRONOBU, NAKATOMI, MASAO, TAKENAKA, SHINOBU, SHIMA, KIYOSHI, NAMBA, KOHJI, HIRAOKA, TAKESUKE, FUJISAKI, KUNIO, NAKAGAMA, HIDEKI, OHTSU, TATSUYA, HISAMITSU, FUKIKO, INOUE, KENJIRO, SUGIYAMA, KOHTARO
• Format: Article
• Language: Japanese
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin - therapeutic use; Bacterial Infections - drug therapy; Bronchitis - drug therapy; Drug Therapy, Combination - therapeutic use; Female; Humans; Japan; Male; Middle Aged; Pneumonia - drug therapy; Respiratory Tract Infections - drug therapy; Sulbactam - therapeutic use
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.44.150

Clinical efficacy and safety of sultamicillin (SBTPC) in patients with lower respiratory tract infections, mainly pneumonia and bronchitis, have been evaluated in a multicenter trial by 19 institutions in the Kyushu area during a period of 12 months from December 1988 to November 1989. 1. Clinical evaluation was made in 132 patients and efficacy rates of SBTPC were 80.0% (28/35) for pneumonia, 78.5% (73/93) for bronchitis and 100% for the remaining 1 patient with other respiratory tract infections. The overall efficacy rate was 79.1% (102/129). 2. Clinical efficacy rate of SBTPC for respiratory tract infections in patients with underlying diseases such as chronic bronchitis, old pulmonary tuberculosis etc., was 75.0% (60/80) which was not significantly different from the efficacy rate of 85.7% (42/49) in patients without underlying diseases. 3. Of 13 patients who failed to respond to previous antibiotic treatments, 8 (61.5%) were effectively treated with SBTPC. 4. Clinical efficacy rates against infections caused by single species of organisms were 90.9% (10/11) for Haemophilus influenzae, 100% (8/8) for Streptococcus viridans and 100% (3/3) for Staphylococcus aureus. The overall clinical efficacy rate in all cases of monomicrobial infections was 88.6% (31/35), in polymicrobial infection 45.5% (5/11) and the overall efficacy rate in cases in which causative bacteria were identified was 78.3% (35/46). 5. Adverse reactions occurred in 6.8% (9/132) of the patients. The symptoms included allergic reaction in 1 patient, gastrointestinal system disorders in 7 patients and general fatigability in 1 patient. As abnormalities in laboratory test values, elevations of Al-P, GOT, and GPT were observed in 3 patients during the study, but returned to normal after discontinuation of SBTPC administration. 6. SBTPC is a useful antibiotic in the treatment of lower respiratory tract infections under the current medical environment where resistant organisms which produce β-lactamases have been increasing.