Inflammation and Collagenase Production in Rats with Adjuvant Arthritis Reduced with 13-cis-Retinoic Acid

Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4612), p.756-758
Main Authors: Brinckerhoff, Constance E., Coffey, John W., Sullivan, Ann C.
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis - drug therapy
Arthritis, Experimental - drug therapy
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cultured cells
Dosage
Female
Fibrinogen - blood
Inflammation
Inflammation - drug therapy
Joint diseases
Male
Medical sciences
Medication administration
Microbial Collagenase - biosynthesis
Pharmacology. Drug treatments
Prostaglandins E - biosynthesis
Rats
Retinoids
Rheumatoid arthritis
Sex Factors
Tretinoin - therapeutic use
Vehicles
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Summary:Oral administration of 13-cis-retinoic acid (40 or 160 milligrams per kilogram of body weight daily) significantly reduced the inflammation associated with developing and established adjuvant arthritis, an experimentally induced arthritis in rats that resembles human rheumatoid arthritis. The amount of collagenase secreted in tissue culture by adherent cells isolated from the inflamed joints of adjuvant rats treated with 13-cis-retinoic acid also decreased as compared to the amount secreted by cells from vehicle-treated adjuvant rats. Collagenase is important in the joint destruction accompanying rheumatoid arthritis. The successful use of retinoids in the treatment of this proliferative but nonmalignant disorder demonstrates a new application of these compounds.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6308759