Persistent hyperthyrotropinaemia since the neonatal period in clinically euthyroid children

We describe three children, now aged between 5 and 6 years, with a persistent mild hyperthyrotropinaemia since the neonatal period and normal levels of thyroid hormones. The increased thyroid stimulating hormone concentration is not artefactual and is not caused by antibody interferences. Their grow...

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Bibliographic Details
Published in:European journal of pediatrics 1991-03, Vol.150 (5), p.308-309
Main Authors: TYFIELD, L. A, ABUSREWIL, S. S. A, JONES, S. R, SAVAGE, D. C. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Endocrinopathies
Humans
Hypothyroidism - blood
Hypothyroidism - diagnosis
Infant
Infant, Newborn
Medical sciences
Thyrotropin - blood
Thyroxine - blood
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Summary:We describe three children, now aged between 5 and 6 years, with a persistent mild hyperthyrotropinaemia since the neonatal period and normal levels of thyroid hormones. The increased thyroid stimulating hormone concentration is not artefactual and is not caused by antibody interferences. Their growth and development is normal and none has received thyroid hormone replacement. We believe that they have compensated hypothyroidism, and that before the advent of screening for congenital hypothyroidism these children would have presented in mid-childhood with juvenile hypothyroidism.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF01955927