Muscle Sympathetic Nerve Activity in Renovascular Hypertension and Primary Aldosteronism

Previous studies, including our own, have demonstrated that muscle sympathetic nerve activity (MSNA) is increased in patients with essential hypertension compared with normotensive subjects. However, the features of sympathetic nerve activity are still unknown in secondary hypertension. We examined...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-06, Vol.17 (6, Part 2), p.1057-1062
Main Authors: Miyajima, Eiji, Yamada, Yutaka, Yoshida, Yohko, Matsukawa, Toshiyoshi, Shionoiri, Hiroshi, Tochikubo, Osamu, Ishii, Masao
Format: Article
Language:English
Subjects:
Adolescent
Adult
Angiography
Angioplasty, Balloon
Angiotensin II - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Humans
Hyperaldosteronism - physiopathology
Hypertension, Renovascular - diagnostic imaging
Hypertension, Renovascular - physiopathology
Hypertension, Renovascular - therapy
Medical sciences
Middle Aged
Muscles - innervation
Reference Values
Renal Circulation
Renin - blood
Sympathetic Nervous System - physiopathology
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Summary:Previous studies, including our own, have demonstrated that muscle sympathetic nerve activity (MSNA) is increased in patients with essential hypertension compared with normotensive subjects. However, the features of sympathetic nerve activity are still unknown in secondary hypertension. We examined MSNA in eight patients with renovascular hypertension and in 11 patients with primary aldosteronism. Twenty patients with essential hypertension and 20 normotensive subjects who were age-matched to the patients with renovascular hypertension and those with primary aldosteronism were also studied. The MSNA of a bundle of the tibial nerve was recorded by microneurography in supine subjects and expressed as both burst rate (bursts/min) and burst incidence (bursts/100 heart beats). Plasma renin activity and the plasma concentration of angiotensin II and aldosterone were also measured. MSNA was increased in the patients with renovascular hypertension compared with the patients with primary aldosteronism and those with essential hypertension and the normotensive subjects (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.17.6.1057