Androgen Receptor and the Testes Influence Hypertension in a Hybrid Rat Model

The objective of this study was to determine if males with a deficient androgen receptor would develop hypertension when crossed with a hypertensive parent Female King-Holtzman rats (n=15), heterozygous for the testicular feminization (Tfm) gene, were crossed with male spontaneously hypertensive rat...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-06, Vol.17 (6, Part 2), p.1104-1110
Main Authors: Ely, Daniel L, Salisbury, Ron, Hadi, Disha, Turner, Monte, Johnson, Mark L
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Chemical Analysis
Blood Pressure
Cardiology. Vascular system
Endocrine Glands - pathology
Experimental diseases
Female
Feminization - genetics
Genes
Heterozygote
Hybridization, Genetic
Hypertension - genetics
Hypertension - physiopathology
Male
Medical sciences
Organ Size
Ovariectomy
Rats
Rats, Inbred SHR - genetics
Rats, Inbred SHR - physiology
Receptors, Androgen - physiology
Testis - physiopathology
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Summary:The objective of this study was to determine if males with a deficient androgen receptor would develop hypertension when crossed with a hypertensive parent Female King-Holtzman rats (n=15), heterozygous for the testicular feminization (Tfm) gene, were crossed with male spontaneously hypertensive rats (SHR), and blood pressure was measured weekly from 5–14 weeks in the F1 hybrid males. Approximately 50% of the F1 hybrid males were Tfm males and androgen receptor-deficient, and 50% were normal. Blood pressure in the parent King- Holtzman males, Tfms, and female rats was also followed for the same time period. The F1 normal male hybrids had a significantly higher (p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.17.6.1104