Surgery in recurrent malignant melanoma

Seventy‐nine consecutive patients with resectable, recurrent malignant melanoma were treated with surgical excision, followed by adjuvant chemotherapy. Of 7 Stage IIIA patients, 6 remain alive; 5 are disease‐free at 27 months. Of 33 patients with advanced stage IIIB disease with fixed tumor masses,...

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Bibliographic Details
Published in:Cancer 1983-10, Vol.52 (7), p.1342-1345
Main Authors: Karakousis, Constantine P., Moore, Robert, Holyoke, Edward D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Humans
Lymphatic Metastasis
Medical sciences
Melanoma - pathology
Melanoma - surgery
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Recurrence
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Seventy‐nine consecutive patients with resectable, recurrent malignant melanoma were treated with surgical excision, followed by adjuvant chemotherapy. Of 7 Stage IIIA patients, 6 remain alive; 5 are disease‐free at 27 months. Of 33 patients with advanced stage IIIB disease with fixed tumor masses, including 16 cases that involved two nodal groups, 10 patients (30%) remain disease‐free at 30 months. Of 12 Stage IIIAB patients, one remains disease‐free at 26 months. Of 27 Stage IV patients, 7 (25%) remain disease‐free at 36 months. Characteristic of those patients who remain disease‐free is the initial presence of 3 or less discrete metastatic lesions, and a long prior disease‐free interval. Surgical removal of metastatic lesions of malignant melanoma, in combination with chemotherapy, offers improved palliation in patients with a small number of metastatic lesions and a long previous disease‐free interval.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19831001)52:7<1342::AID-CNCR2820520733>3.0.CO;2-C