Coloured complexes of all- trans-retinal with benzocaine and other local anesthetics

Coloured Schiff base complexes with λ max values of 500 rim or above were formed between the visual pigment all- trans-retinal and the local anaesthetics procaine (λ max = 533 nm), benzocaine (4-amino-benzoic acid ethyl ester, λ max = 535 nm), 3-amino-benzoic acid ethyl ester (λ max = 500 nm) and 2-...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1991, Vol.8 (2), p.183-188
Main Authors: Fowler, G.J.S., Devonshire, R.
Format: Article
Language:English
Subjects:
Anesthetics, Local - chemistry
benzocaine
Benzocaine - chemistry
Biological and medical sciences
Colorimetry - methods
Fundamental and applied biological sciences. Psychology
local anaesthetic
Models, Theoretical
procaine
retinal
Retinal Pigments
Retinaldehyde
Retinaldehyde - chemistry
Schiff base
Schiff Bases
Spectrophotometry - methods
Vertebrates: nervous system and sense organs
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Summary:Coloured Schiff base complexes with λ max values of 500 rim or above were formed between the visual pigment all- trans-retinal and the local anaesthetics procaine (λ max = 533 nm), benzocaine (4-amino-benzoic acid ethyl ester, λ max = 535 nm), 3-amino-benzoic acid ethyl ester (λ max = 500 nm) and 2-amino-benzoic acid ethyl ester (λ max = 509 nm) in methanol acidified with HCl. The anaesthetics lidocaine and urethane failed to form coloured compounds with λ max values greater than 500 nm under the same conditions. The relevance of these observations to the effect of anaesthetics on the visual pigments is discussed.
ISSN:1011-1344
1873-2682
DOI:10.1016/1011-1344(91)80057-O