Family Distances as a Measure of Hidden Consanguinity: A Reappraisal

We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origi...

Full description

Saved in:
Bibliographic Details
Published in:Human heredity 1991-01, Vol.41 (1), p.12-16
Main Authors: Swaving, Janny, Groenewegen, Alex, Kamstra, Aukje, te Meerman, Gerard J., ten Kate, Leo P.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Aberrations - genetics
Chromosome Disorders
Consanguinity
Female
Fundamental and applied biological sciences. Psychology
Genes, Recessive
Genetics of eukaryotes. Biological and molecular evolution
Humans
Male
Netherlands
Original Papers
Pedigree
Prevalence
Random Allocation
Rural Population
Urban Population
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We compared the family distances of patients with autosomal recessive disorders with those of a random control group and a matched control group. Only in the great-grandparental generation were weak-significant differences found. We also found that the family distances of persons with an urban origin were significantly larger than those of persons with a rural origin. In our study, family distance seems to be a more powerful measure of hidden consanguinity than the parental distance.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153967