Morphological grades of regression in osteosarcoma after polychemotherapy-study COSS 80

The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- an...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1983, Vol.106 (S1), p.21-24
Main Authors: SALZER-KUNTSCHIK, M, DELLING, G, BERON, G, SIGMUND, R
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - administration & dosage
Biological and medical sciences
Bone Neoplasms - drug therapy
Bone Neoplasms - pathology
Chemotherapy
Drug Therapy, Combination
Evaluation Studies as Topic
Humans
Medical sciences
Osteosarcoma - drug therapy
Osteosarcoma - pathology
Pharmacology. Drug treatments
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Summary:The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patients could be found. Tumors under 10 cm in length responded better to chemotherapy than those of greater length and there was a good correlation between the clinical estimation of tumor regression and progression and the histologic grade of regression.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF00625047