Interferon Production Associated with the Ageing of Primary Chick Embryo Cells Is Not Caused by Priming

Department of Measles Virus, National Institute of Health of Japan, 4-7-1, Gakuen, Musashimurayama-shi, Tokyo 190-12, Japan The presence of a low level of interferon (IFN) activity was demonstrated in aged culture medium of primary chick embryo (CE) cells. The endogenous cytoplasmic level of 2'...

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Bibliographic Details
Published in:Journal of general virology 1983-09, Vol.64 (9), p.2017-2020
Main Authors: Kohase, Masayoshi, Saito, Sakura, Iizuka, Eriko, Matsumura, Haruo, Kohno, Seiya
Format: Article
Language:English
Subjects:
2',5'-Oligoadenylate Synthetase - metabolism
Ageing, cell death
Aging - drug effects
Animals
Biological and medical sciences
Cell physiology
Chick Embryo - immunology
Fundamental and applied biological sciences. Psychology
Immune Sera - immunology
Interferons - biosynthesis
Molecular and cellular biology
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Summary:Department of Measles Virus, National Institute of Health of Japan, 4-7-1, Gakuen, Musashimurayama-shi, Tokyo 190-12, Japan The presence of a low level of interferon (IFN) activity was demonstrated in aged culture medium of primary chick embryo (CE) cells. The endogenous cytoplasmic level of 2',5'-oligoadenylate (2',5'-A) synthetase activity also increased during cell ageing. This increase was suppressed by addition of antiserum against chick IFN. In contrast, anti-chick IFN serum did not inhibit the ageing effect, i.e. the enhanced production of IFN upon induction after a prolonged preincubation of CE cells. This result indicates that the occurrence of the ageing effect is not mediated by the IFN system which had been expressed spontaneously. Keywords: IFN, chick cells, ageing, priming Received 28 February 1983; accepted 20 May 1983.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-64-9-2017