Neutrophil chemotactic factors in synovial fluids of patients with lyme disease

We examined synovial fluid samples from 14 patients with Lyme arthritis for the presence of neutrophil chemotactic factors. Thirteen of the synovial fluids stimulated chemotaxis of normal human neutrophils. The chemotactic activity was heat‐sensitive and was not inhibited by antibody to C5a or antib...

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Bibliographic Details
Published in:Arthritis and rheumatism 1991-06, Vol.34 (6), p.770-775
Main Authors: Georgilis, Kostis, Noring, Richard, Steere, Allen C., Klempner, Mark S.
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Borrelia infections
Chemotactic Factors - analysis
Human bacterial diseases
Humans
Infectious diseases
Lyme Disease
Medical sciences
Neutrophils
Synovial Fluid - chemistry
Tropical bacterial diseases
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Summary:We examined synovial fluid samples from 14 patients with Lyme arthritis for the presence of neutrophil chemotactic factors. Thirteen of the synovial fluids stimulated chemotaxis of normal human neutrophils. The chemotactic activity was heat‐sensitive and was not inhibited by antibody to C5a or antibody to interleukin‐8, or by a competitive inhibitor of the chemotactic peptide f‐Met‐Leu‐Phe. A culture supernatant of Borrelia burgdorferi also contained neutrophil chemoattractants. Chromatography demonstrated that the chemoattractants in the synovial fluid samples were different from those in the B burgdorferi culture supernatant. One of the major chemotactic factors in Lyme disease synovial fluid had a calculated molecular weight of 13,900. We conclude that a novel, host‐derived chemoattractant is present in the synovial fluid of patients with Lyme disease.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780340620