A behavioral profile of two dystrophic mouse strains

Samples of the spontaneous activity of individual mice of two dystrophic strains (129/ReJ dy/dy and C57BL/6J dy/dy), their littermates (heterozygous or normal), and parent-strain animals were intermittently recorded on video over a 24-h period. Twelve behavioral categories were derived from all beha...

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Bibliographic Details
Published in:Behavior genetics 1983-05, Vol.13 (3), p.225-238
Main Authors: FROSTHOLM, A, BENNETT, W, LYNCH, G
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - physiology
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Female
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genotype
Male
Mice
Mice, Inbred Strains
Muscular Dystrophy, Animal - genetics
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Summary:Samples of the spontaneous activity of individual mice of two dystrophic strains (129/ReJ dy/dy and C57BL/6J dy/dy), their littermates (heterozygous or normal), and parent-strain animals were intermittently recorded on video over a 24-h period. Twelve behavioral categories were derived from all behaviors observed. Dystrophic mice showed significantly higher numbers of grooming-related seizures and instances of feeding than their unaffected controls. The frequency of each of these behaviors increased during the dark portion of the laboratory light cycle. Hard and most food consumption was also measured in dystrophic and control animals of both strains. Young dystrophic animals ate considerably more hard food (relative to body weight) than controls, while older, severely dystrophic mice ate less. However, when given moist food, the latter animals increased their food intake over that of controls.
ISSN:0001-8244
1573-3297
DOI:10.1007/BF01071868